After a protracted battle with COVID-19, the vaccine's administration has undoubtedly delivered a sigh of relief. A double dose of coronavirus vaccine can reduce the risk of infection and prevent the virus from generating a major infection that could lead to hospitalization or death. However, in the case of those with reduced immunity, the vaccine's efficiency and the level of protection it might provide are unknown.

People with weakened immunity have an underlying illness that impairs their defenses, putting them at risk of infection. To put it another way, such people's immune systems aren't powerful enough to combat the virus and prevent it from creating major health problems. This includes people who have cancer, have had an organ transplant, have metabolic illnesses, or have autoimmune conditions and are receiving drugs that modify their immune response. Most individuals are left wondering whether or not the vaccine will work on them.

Currently, the majority of vaccinations on the market contain virus-derived material. When these materials enter our bodies, our cells urge our immune cells to produce a harmless protein that mimics the virus's structure. The body destroys the genetic material from the vaccine once our cells have made copies of the protein. If we were infected with the virus that causes COVID-19 in the future, our bodies will store the structure of the protein in memory cells to help us fight it. The immune system of immunocompromised people does not work as well as it should. It's thought that the immune system won't be able to produce a strong enough reaction to the vaccine.

According to a study focused on organ transplant recipients, they have a weak antibody response to the COVID-19 vaccinations. Furthermore, only 17% of those who took part in the trial produced a detectable quantity of antibody response within 2 weeks of receiving the first dose of an mRNA vaccine. Antibody responses were evident in 54% of subjects after the second dose. The study's authors also discovered that transplant recipients were at a high risk of infection and catastrophic complications. It's crucial to realize, though, that the study focused solely on organ transplant patients.

Giving immunocompromised persons an extra booster dose, according to medical experts, may reduce the chance of infection and hospitalization. The third dose has the potential to boost the immunological response and antibody response to COVID-19. It would be easier to indicate the necessity for the fourth and fifth doses based on the effectiveness of the third dose. Following all COVID-related precautionary standards is the best way to stay safe at this point. When going out, wear a mask, keep a six-foot distance, practice good hygiene, and get vaccinated.